Is there a role for CYP2E1 in ethanol-induced fatty liver? In the IG infusion model, Kono et al [11] reported that after feeding ethanol for 4 weeks, there was no difference in ethanol-induced steatosis between CYP2E1 knockout mice and wild type mice. Similarly, in this model, Wan et al [47] reported that ethanol infusion for 21 days promoted fat accumulation in CYP2E1 knockout mice but, surprisingly, not in the wild type mice. In contrast, the CYP2E1 inhibitor chlormethiazole (CMZ) was reported to blunt ethanol-induced fatty liver in the IG model [9].
