While chronic cannabis use is known to have detrimental effects on neural circuitry43,44, and the networks underlying CUD are beginning to be identified, we did not identify any effects of CUD on visual oscillatory activity in this sample. Cannabinoid-1 receptors (CB1Rs) control the release of neurotransmitters such as GABA and glutamate when activated by cannabinoids, whether that being naturally occurring or from marijuana. Indeed, disruptions in oscillatory activity have been identified with acute cannabis use, and GABAergic interneurons have been deliberated as the cause of such oscillatory disruption9. However, our study did not assess oscillatory activity in the context of short-term drug effects, and such acute effects of cannabis are unlikely to generalize to our sample of chronic users who had not recently consumed such substances. Still other studies have identified alterations in chronic cannabis users in oscillatory activity related to attentional processing45,46. Compared to these studies however, the current study utilized a paradigm that did not utilize an attentional comparison. Additionally, our study was designed to investigate the effects of use disorder, and therefore our test of the main
