To identify pathways or gene sets implicated by the BMI-associated loci, we first used Meta-Analysis Gene-set Enrichment of varia NT Associations (MAGENTA)24, which takes as input pre-annotated gene sets, and then tests for overrepresentation of gene set genes at BMI-associated loci. We found enrichment (false discovery rate (FDR) < 0.05) of seven gene sets, including neurotrophin signalling. Other highlighted gene sets related to general growth and patterning: basal cell carcinoma, acute myeloid leukaemia, and hedgehog signalling (Supplementary Table 20a, b).
