As a complementary approach, we examined overlap of associated variants at the 97 loci (r2 > 0.7 with the lead SNP) with five regulatory marks found in most of the 14 selected cell types from brain, blood, liver, pancreatic islet and adipose tissue from the ENCODE Consortium22 and Roadmap Epigenomics Project23 (Supplementary Table 19a–c). We found evidence of enrichment (P < 1.2 × 10−3) in 24 out of 41 data sets examined. The strongest enrichment was observed with promoter (histone 3 Lys 4 trimethylation (H3K4me3), histone 3 Lys 9 acetylation (H3K9ac)) and enhancer (H3K4me1, HeK27ac) marks detected in mid-frontal lobe, anterior caudate, astrocytes and substantia nigra, supporting neuronal tissues in BMI regulation.
