Unrelated subjects who met DSM criteria for cocaine dependence and control subjects with no evidence for dependence on any addictive substance were assembled from three studies. Family study of cocaine dependence subjects were recruited from treatment centers close to St. Louis. Mo; 55% of contacted subjects participated. Community-based comparison subjects were recruited through driver's license records from the Missouri Family Registry and were matched to cocaine dependent subjects based on date of birth, ethnicity, gender, and zip code. Eighty percent of screened and eligible comparison subjects participated. Other participants came from individuals who participated in the collaborative study on the genetics of alcoholism and the collaborative study on the genetics of nicotine dependence. Dependent individuals displayed DSM dependence on cocaine as reflected in the dbGAP variable phv00066444.v1.p1. Controls displayed no DSM dependence on cocaine, nicotine, alcohol, marijuana, opioids or other drugs. We identified 481 dependent and 1053 control unrelated European-American and 516 dependent and 409 control unrelated African-American subjects for this analysis. Genotyping for these samples was performed using Illumina 1M SNP arrays at the Center for Inherited Disease Research
