To seek patterns of human brain expression for the genes identified herein, we identified 846 human cDNA libraries constructed from brains with modest or no pathology in dbEST. We identified 1) all entries and 2) “more reliable” entries with correct genomic orientation and either evidence for polyA tail or spliced structure (CYL and GRU, in preparation). For each brain region, we assessed the p-value for over-representation of expression of the addiction-associated genes using hypergeometric distribution tests and false discovery rate (FDR) corrections, considering Q-values<0.05 as statistically significant.
