Chunk #51 — MATERIALS AND METHODS — QC and association testing — Quality control

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Novel common copy number variation for early onset extreme obesity on chromosome 11q11 identified by a genome-wide analysis.

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Concerning the QC related to the qPCR experiments for CNVR 11q11, only those copy number calls with a confidence value (by CopyCaller 1.0) of at least 0.98 without evidence for Mendelian inconsistencies were followed-up. Subsequently, the full set of all 772 families successfully assessed by qPCR was analysed for deviations from Hardy–Weinberg equilibrium (46) resulting in a two-sided exact P-value of 0.95 in the parents.