Beyond severe obesity, individuals in the UK Biobank who carried high GPS were at increased risk for six common cardiometabolic diseases, including a 28% increased risk of coronary artery disease, a 72% increased risk for diabetes mellitus, 38% increased risk for hypertension, 34% increased risk for heart failure, 23% increased risk for ischemic stroke, and 41% increased risk for venous thromboembolism (p < 0.05 for each; Figure 4).
