We next determined the relationship between high polygenic score and all-cause mortality. Death following enrollment occurred in 8,102 (2.8%) participants over a median follow-up of 7.1 years, including 940 (3.3%) of those in the top decile of the polygenic score distribution and 7,162 (2.8%) in the remainder of the distribution (p < 0.0001). In a survival analysis that additionally included time to death in the statistical model, high polygenic score was associated with a 19% increased risk of incident mortality (p < 0.0001).
