From October 1997 through June 2010, 1,403 persons agreed to annual detailed clinical evaluation and donation of brain, spinal cord, nerve, and muscle at the time of death. Of these, 1,372 have completed their baseline clinical evaluation: 72.7% were women; 86.9% were white, non-Hispanic; their mean age was 80.0 years; and mean education was 14.3 years, with 34.0% with 12 or fewer years of education. To date, there have been 250 cases of incident dementia and 238 cases of incident AD with or without a coexisting condition. At this time, over 900 subjects from either ROS or MAP are deceased and have frozen brain tissue available for data generation. To avoid population stratification artifacts in the genetic analyses, the first 500 subjects were randomly selected from among those subjects that are self-reported to be of white, non-Hispanic ancestry, and have genome-wide genotype data (N = 1,709 for the entire ROS and MAP studies) that confirm this self-reported ancestry.
