From January 1994 through June of 2010, 1,148 persons agreed to annual detailed clinical evaluation and brain donation at the time of death. Of these, 1,139 have completed their baseline clinical evaluation: 68.9% were women; 88.0% were white, non-Hispanic; their mean age was 75.6 years; and mean education was 18.1 years. To date, there have been 287 cases of incident dementia and 273 cases of incident AD with or without a coexisting condition.