Globally, our findings could be interpreted either as the expression of long-term changes in mechanisms of neural plasticity of brain networks (neurodegeneration hypothesis), or resulting from prolonged exposition to antipsychotics and the associated dysfunctions in inhibitory/excitatory neurotransmission (antipsychotic driven neurodegeneration hypothesis). Current study is not able to discriminate between these two mechanisms and the clinical applicability of these findings has to be determined with prospective studies.
