Our study reports for the first time differences in resting-state EEG-SFC functional connectivity within and between brain areas in medicated schizophrenic patients and differences between short duration vs. long duration of the schizophrenic illness. The main findings were a diffuse increase in EEG-SFC in delta and theta bands and a decreased frontal alpha EEG-SFC. Interestingly, low frequency EEG-SFC was more evident in patients with long disease duration while decreased EEG-SFC appeared to be a stable phenomenon throughout the disease course, supporting the idea of functional specificities of the EEG bands (Uhlhaas and Singer, 2010). Lastly, EEG-SFC in the gamma band showed a complex pattern characterized by increase in SDD and decrease in LDD, which might be partially explained by different inhibitory/excitatory patterns of dysfunction in early-stage vs. chronic schizophrenia.
