Some limitations in the current study must be considered. The pharmacological therapy could be a potential confounding factor on connectivity indices of SCZ. Dopamine receptor antagonists can alter FC and network parameters (Achard and Bullmore, 2007). Our patients had been treated with antipsychotics for several years; however, SDD and LDD patients didn't show significant differences in antipsychotic dosage (in chlorpromazine equivalents) making it unlikely for the reported differences in EEG-SFC metrics between the two groups to be attributable to current treatment effects. A further potentially limiting factor could be the relatively low spatial resolution allowed by the number of channels (37) used in our EEG recordings. While there is sufficient evidence to suggest that increased spatial sampling is one of the factors in achieving higher localization accuracy in EEG studies (Liu et al., 2002), the size of cortical patches used in the present study to define ROIs is well within the resolution allowed by the spatial sampling.
