Under placebo, there was no greater activation in AO compared to ApCO, even at a trend level of p < 0.05. During alcohol infusion, however, AO showed greater activation than ApCO in some of the same regions that appeared in the comparison to NApO: Medial frontal cortex [−10, 64, 10] and right lateral orbitofrontal cortex [34, 36,−20] (Fig. 3C). We then defined 12 mm diameter spherical search regions centered on the coordinates that activated in the [AO > NApO]alcohol contrast and found significant posterior cingulate/retrosplenial area and precuneus activation foci (see Table 2).
