During alcohol infusion (Table 2), there was significantly more activation from AO than from NApO (Fig. 3B) in the NAc/olfactory tubercle area (two local maxima at [6, 0, −10] and [4, 12,−8]). There was also greater AO activation compared to NApO in medial/ventromedial frontal cortex (peak maximum at [0, 48, −6]), posterior cingulate/retrosplenial area (peak maximum at [2, −42, 30]), in the precuneus (peak maximum at [0, −66, 24]) and lateral orbitofrontal cortex [34, 34, −14] (Fig. 4B). Within the anatomically defined NAc ROI, AO provoked significantly greater activation in the left NAc than did NApO during alcohol infusion (p = 0.05); this comparison in the right NAc remained insignificant (p = 0.1).
