During placebo infusion, AO elicited no greater activation than NApO, although at a low trend threshold of p < 0.05, a small degree of greater AO than NApO activation was apparent in mesial frontal cortex [−8, 56, 0], the precuneus area [−8,−60, 16] (Fig. 3A), and right lateral orbitofrontal cortex [28, 34,−10] (Fig. 4A). Within the anatomically defined NAc ROIs (Fig. 5B;Fig. 5A for ROI definition), there was no greater activity from AO than from NApO in either the left or the right NAc (p’s > 0.24).