We have recently added support for another model organism, rat (Rattus norvegicus), and are developing zebrafish (Danio rerio) and Escherichia coli as our next two model organisms to add. Our data set for the supported organisms is updated approximately twice a year, although we occasionally perform smaller updates when large interaction studies are published. Our front page provides up-to-date statistics on the number of interactions and networks in our database. We perform comparisons between the current version of our database and previous ones to identify data issues and track data set growth (see Table 2). We are unable to make previous data releases available through the Web site, but we do archive them for download, and they can be accessed through our Cytoscape app (6). Our app has the same functionality as the Web site, and queries in the app should give identical results as Web site queries. Web site users can download a JSON file to store their search parameters by selecting the ‘Save search parameters as JSON’ option in the File menu of the results page. This file can be read into our Cytoscape app to exactly reproduce the saved search.
