A locus was identified on chromosome 10 at 87 cM with a LOD score of 2.7 that has also been identified previously in several genome scans for a number of substance abuse related traits. For instance this area was found to be linked (LOD= 4.17) to smoking phenotypes in the Midsouth Tobacco Family Study in African Americans (Li et al., 2006), as well as to alcohol dependence in the COGA sample (Agrawal et al., 2008) and in a dense genomewide linkage scan for alcohol dependence in African Americans (Gelernter et al., 2009). Interestingly, this site appears to be within 30cM of an area identified in two studies investigating the low response to alcohol as assessed using an alcohol challenge study (Wilhelmsen et al., 2003; Schuckit et al., 2005) as well as a study of COGA participants using the SRE FIRST FIVE phenotype (Schuckit et al., 2001a). It has been suggested by Schuckit et al., (2005) that one potentially promising gene in the support region on chromosome 10 is KCNMAI, which has an important role in the effects of alcohol on
