FIVE phenotype (Schuckit et al., 2001a). It has been suggested by Schuckit et al., (2005) that one potentially promising gene in the support region on chromosome 10 is KCNMAI, which has an important role in the effects of alcohol on potassium channels (Davies et al., 2003). The concordance between studies in identifying several loci in the genome that are associated with substance dependence phenotypes and the SRE further suggests that the search for candidate genes within these locations may be productive in identifying some general mechanisms that may underlie variation in a number of phenotypes.
