Another area that was identified on chromosome 11 at 13 cM with a LOD score of 1.97 for the FIRST FIVE SRE phenotype was also within 17 cM of a site identified previously for an EEG alpha power phenotype in this Indian population at @30 cM with a LOD score of 2.98. This site also appears to be close to a site identified in a genome scan for opioid dependence in a sample of small nuclear families recruited from 4 populations of participants (Gelernter et al., 2006), and also overlaps with a site identified for alcohol dependence in a Southwest Indian tribe (Long et al., 1998) as well as several smoking phenotypes (Wang et al., 2005; Li et al., 2008; Loukola et al., 2008).