Chunk #4 — 2 MODEL

Source

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data.

Embedded

yes

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The NB distribution reduces to Poisson when ϕg=0. In some DGE applications, technical variation can be treated as Poisson. In general, ϕg represents the coefficient of variation of biological variation between the samples. In this way, our model is able to separate biological from technical variation.