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Chunk #73 — STAR★METHODS — QUANTIFICATION AND STATISTICAL ANALYSIS — Expression-based mapping of SNPs — Defining high-confidence genes across all gene-based analysis methods

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Trans-ancestry genome-wide study of depression identifies 697 associations implicating cell types and pharmacotherapies.
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Other gene finding analyses based on the proximity of genes to MDD associated variation are often confounded by LD (linking lead variants to the nearest gene (within 50kb), fastBAT and H-MAGMA), leading to multiple genes within a given locus to be associated. These methods are therefore considered auxiliary, and do not provide sufficient evidence to define high confidence associations. Furthermore, the PsyOPS gene prioritization approach was considered auxiliary given it also links associated variants to genes based on proximity, in addition to other information). Gene lists from auxiliary gene finding analyses were generated using the following criteria: