Chunk #74 — STAR★METHODS — QUANTIFICATION AND STATISTICAL ANALYSIS — Expression-based mapping of SNPs — Gene set enrichment analysis: Synaptic Gene Ontologies (SynGO)

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Trans-ancestry genome-wide study of depression identifies 697 associations implicating cell types and pharmacotherapies.

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We conducted gene set enrichment tests of Gene Ontology (GO)88,89terms for biological processes, molecular mechanisms, and cellular components that have been expertly curated for synapse function using SynGO.15 We input genes from the high-confidence gene list (identified with finemapping, TWAS, or PWAS) into the SynGO Portal <https://syngoportal.org/> with “brain expressed” genes as the background set.