As one expects, the two-point analysis of the neurophysiology phenotype gave lower linkage signals than the multipoint analysis with a much greater difference evident with SNPs than with microsatellites. Such differences are often exaggerated in regions of high LD. In addition, it is known that single-point analysis with SNPs has substantially lower information than with microsatellites. In this case we believe that the differing linkage results are more due to reduced information in the SNPs than to LD in the region.
