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Chunk #12 — Discussion

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Microsatellites versus single-nucleotide polymorphisms in linkage analysis for quantitative and qualitative measures.
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neurophysiology phenotype, the LOD scores using the microsatellite, Affymetrix, and sparse Illumina maps were nearly the same. The dense Illumina map gave a marginally higher LOD score, and this may reasonably be attributed to high LD in this region (7 of 19 markers were dropped for the sparse map). Although the LOD scores varied more with the quantitative trait than with the qualitative trait for the two Illumina maps, this may be due more to LD in the region than to the different trait types. These results indicate that a sparse map as constructed in [8] can carry sufficient information for linkage.