SNP heritability was partitioned by functional category and tissue association using LD score regression40. Partitioning was performed for 53 overlapping functional categories, as well as 220 cell-type-specific annotations grouped into 10 cell-type groups, as described in Finucane et al. 40. For both sets of annotations we used previously computed LD scores and allele frequencies from European ancestry samples in the 1000 Genomes Project (available on see URLs).
