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Chunk #7 — MATERIALS AND METHODS — Study sample 1: Collaborative Study on the Genetics of Alcoholism (COGA)

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Associations between alcohol use disorder polygenic score and remission in participants from high-risk families and the Indiana Biobank.
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more DSM-5 AUD criteria occurring within the same 12-month period (American Psychiatric Association, 2022). Among individuals who met lifetime AUD criteria, those who reported no current criteria other than craving for at least 12 consecutive months were coded as 12-month remission. We further characterized remission as abstinent (no alcohol consumption) and non-abstinent (still consuming alcohol in any amount). Participants with lifetime AUD who never met remission criteria were defined as having current AUD (i.e., not remitted). For participants with more than one interview, AUD and remission were coded if criteria were met at any interview. Individuals who did not meet lifetime criteria for DSM-5 AUD were not included in these analyses. In total, 3,249 EA and 1,163 AA participants were included. The average numbers of interviews were 3.06 (SE 1.96) for EA and 2.75 (SE 1.95) for AA, respectively.