Covariates available in COGA (but not in Indiana Biobank) included AUD duration (years from first AUD onset to remission or the last interview), lifetime maximum alcohol consumption during a 24-hour period (maxdrink24), and maximum lifetime AUD criterion count. History of remission in the family was based on the self-reports of participants’ first-degree relatives who were themselves interviewed about their own history of AUD. First-degree family members who met lifetime AUD criteria were coded as remitted if they reported no current criteria other than craving for at least 12 consecutive months. Individuals with one or more first-degree family members who had a history of remission were coded as having a family history of remission. AUD treatment history was based on participant report of having ever been treated for a drinking problem, and if so, the type of treatment. Professional treatment was coded for participants who accessed an inpatient or outpatient alcohol program, and mutual help for participants who reported ever having attended Alcoholics Anonymous or another mutual help group. Variables representing mutual help only, professional treatment only, and both professional treatment and mutual help (both treatments) were included to account for treatment history.
