Indiana Biobank is a state-wide collaborative effort that combines state-of-the-art centralized biobanking and linked electronic health records (EHR) (Lai et al., 2022b). Each participant’s de-identified EHR data are available via the Indiana Network for Patient Care (INPC) supported by the Regenstrief Institute at Indiana University School of Medicine. Two cohorts from Indiana Biobank were utilized in this study: (1) ascertained to study liver diseases and matched controls (N=575), and (2) ascertained to study substance use disorders (SUD, including alcohol, cannabis, cocaine, opioid, other substances, N=460). Only participants with AUD from both cohorts, determined based on ICD codes (ICD9: 303 (Alcohol dependence syndrome) and 305.0 (Nondependent alcohol abuse); ICD10: F10 (Alcohol related disorders)) (Lai et al., 2022b), were included in the current analyses. Remission was determined based on clinical entry of specific ICD9 (303.03 (Acute alcoholic intoxication in alcoholism, in remission), 303.93 (Other and unspecified alcohol dependence, in remission), and 305.03 (Alcohol abuse, in remission)) or ICD10 codes (F10.11 (Alcohol abuse, in remission) and F10.21 (Alcohol dependence, in remission)), but these did not specify remission type as abstinent or not. These
