The BAF components implicated in ASD and SZ play vital roles in npBAF/nBAF complexes and their switching at mitotic exit; thus, the above mutations may adversely impact multiple stages of development. Notably, synaptic dysfunction is a hallmark of many psychiatric disorders (Zoghbi, 2003) and ASD/SZ-associated BAF mutations are consistent with the important role of the nBAF complexes in the maturation of neurites and synaptic plasticity (Wu et al., 2007; Vogel-Ciernia et al., 2013).
