We also applied Summary-data-based Mendelian Randomization (SMR) analysis43 to the data in concert with dorsolateral prefrontal cortex expression quantitative trait locus (eQTL) data from the CommonMind Consortium44, aiming to identify variants that might be causally linked through expression changes in specific genes (Methods and Supplementary Table 13). After applying a conservative threshold (PHEIDI > 0.05) that prioritized colocalized signals due to a single causal variant43, we identified 22 candidates at 19 loci with false discovery rate (FDR) P < 0.05.
