Chunk #23 — Results — Identifying likely candidates within associated loci

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Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection.

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In total, the combination of FINEMAP, Hi-C and SMR analyses assigned potentially causal genes at 33 genome-wide significant loci and implicated a single gene at 27 of these loci. However, the analyses intersect for only a single gene, ZNF823, indicating the need for more comprehensive functional genomic annotations in CNS- relevant tissues.