Chunk #25 — Potential Biological Mechanism of Hippocampal Sensitivity to AUDs: Impact of Altered GluN and GABAR Signaling in the Hippocampus on Adult Neurogenesis
The explicit functionality of these adult-born cells is still a topic of contention. Hippocampal-sensitive learning has been shown to positively influence proliferation and survival of new neurons [reviewed in Ref. (154)]; inversely, increases in proliferation or survival of newly born neurons can increase performance on hippocampal-sensitive tasks, while reductions or ablations of neuronal proliferation results in problematic cognitive performance [reviewed in Ref. (155)]. Acquisition, retention, and extinction of trace fear conditioning (TFC; a hippocampus sensitive task) has been shown to be sensitive to changes in neurogenesis (156) due to or as a result of its hippocampal-dependence (157), but as yet, investigations into the impact of clinically relevant models of chronic alcohol on TFC performance have not been reported.
