Chunk #24 — Potential Biological Mechanism of Hippocampal Sensitivity to AUDs: Impact of Altered GluN and GABAR Signaling in the Hippocampus on Adult Neurogenesis
Adult mammalian neurogenesis is a widely accepted phenomenon, as evidence demonstrates the existence of mitotically active cells in distinct regions of the brain, one which is the granule cell layer of the DG of the hippocampus. Neurogenesis, or the process of proliferation, differentiation, and maturation of neural progenitor cells to fully functional and integrated neuronal components of the surrounding network (150, 151), has been confirmed in numerous mammalian species, including humans (152). Assessment of cell number and structure at various time points following cell birth can provide insight into the impact of exogenous factors on the neurogenic process in the hippocampus [for comprehensive review of granule cell development see Ref. (153)].
