This sensorimotor network connectivity finding is consistent with other studies that have found deficits in regions involved in motor behavior in FHPs.15 Interestingly, functional connectivity appears to be reduced in participants with AUD in BA6 and other regions implicated in motor behaviors39; however, in AUD, the reductions in connectivity appear to be more pronounced and additionally include fronto-parietal networks implicated in executive control.40 Although more research is clearly warranted, these results suggest that lower excecutive control related connectivity may manifest after years of problematic alcohol use but may not necessarily be present in high-risk, FHP youth. The family history effect appears to be substantially weaker and largely independent of the robust age differences in internetwork connectivity found in this sample. We found differences in internetwork connectivity between the groups 13 to 14 years and 17 to 18 years of age, indicating that although the basic pattern of resting state networks is well established by adolescence,41 the strength of correlation between networks continues to change over a few short years. The general pattern of results points to greater connectivity between networks
