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Chunk #26 — DISCUSSION

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Association Between Age and Familial Risk for Alcoholism on Functional Connectivity in Adolescence.
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indicating that although the basic pattern of resting state networks is well established by adolescence,41 the strength of correlation between networks continues to change over a few short years. The general pattern of results points to greater connectivity between networks in the older age group. However, the cerebellum appears to have very different internetwork connectivity in the two age groups. In the group 13 to 14 years versus 17 to 18 year of age, connectivity was higher between the cerebellum network and sensory/sensorimotor areas. On the other hand, in the group 17 to 18 years versus 13 to 14 years of age, cerebellum connectivity was higher with frontal lobe networks. This could imply a shift in cerebellar connectivity patterns from basic sensorimotor to higher-order cognitive functions. These results are consistent with a recent study that found age differences in cerebellar connectivity; maturation was associated with a shift from cerebellar sensorimotor connectivity to cerebellar cortical connectivity.42 We did not obtain evidence for a family history × age group effect, suggesting that the basic pattern of age differences in internetwork connectivity was similar for both FHP and FHN groups.