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Chunk #11 — Results — miRNA expression-Quantitative Trait Loci (eQTL) analysis

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MicroRNA expression in abdominal and gluteal adipose tissue is associated with mRNA expression levels and partly genetically driven.
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To investigate whether any of the five miRNA eQTL SNPs were directly associated with obesity phenotypes (body mass index and waist hip ratio corrected for BMI), we looked up association p-values in a genome-wide association study with 113,636 subjects from the GIANT consortium) [33], [34]. We found that none of the individual miRNA eQTL-related SNPs had a significant (p-value<0.05) association with either of the two obesity phenotypes (Table S6), providing no direct evidence that the miRNA eQTL SNPs are associated with either of these particular phenotypes.