GWAS results generally do not lie in protein coding regions. 24 A recent report suggested that most SNPs in the NHGRI GWAS catalog 24 were in or in perfect LD with DNase 1 hypersensitive sites. 25 We thus evaluated whether the Sweden + PGC results had significant overlap with DNase 1 hypersensitive sites generated as part of the ENCODE project. 26 We did not find evidence of enrichment (Supplemental Table 8 and Supplemental Figure 10). However, this negative result is strongly qualified by the lack of DNase 1 hypersensitivity data directly relevant to psychiatric disorders.
