overall association between any of the previously reported candidate genes and aggression(Vassos, Collier, & Fazel, 2014). The lack of replication of candidate genes for ASB is consistent with other candidate gene studies in psychiatry, which for the most part have failed to identify reproducible and clinically useful genetic variants(Kendler, 2013). This is partly due to the a priori inferences of the classical candidate gene approach, which increases the chances of false positive findings in the typically small sample sizes of these individual studies(Danielle M. Dick et al., 2015).
