(2006) reporting no association and Lichtermann et al. (2000) reporting a strong association between the presence of any s allele and alcohol dependence. One study (Schuckit et al., 1999) that was also included in the Feinn et al. paper, and a follow-up from this study (Hu et al., 2005), pre-selected all participants based on an estimation of these individuals being at high risk for the development of alcohol problems, and those who did develop alcohol dependence were compared to those who did not. Given that the control group used in these studies was not a true healthy group, these two studies were excluded. Another study (Kweon et al., 2005) reported a violation of HWE in the alcohol dependent group and thus was excluded. Other studies were excluded because they lacked a healthy control group or did not evaluate alcohol dependence diagnosis. Of the remaining 22 identified studies, data was extracted as described above. In cases where insufficient data were available to conduct analyses, corresponding authors were contacted and the needed information was successfully acquired.
