The 22 studies included in the final analysis are described in Table 1. Odds ratios for the association between any s allele and alcohol dependence diagnosis across studies ranged from 0.67-2.23 (see Figure 2). Evaluation of the overall effect size indicated that there was a significant association between alcohol dependence diagnosis and the presence of at least 1 s allele (OR = 1.15, 95% CI = 1.01, 1.30, p < .05). Similar results of a slightly greater magnitude were noted for comparison of participants who were homogeneous (s/s) for the s allele (OR = 1.21, 95% CI = 1.02, 1.44, p < .05).
