Chunk #21 — Results — Replication of trans-eQTLs in monocytes and four additional primary tissues

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Trans-eQTLs reveal that independent genetic variants associated with a complex phenotype converge on intermediate genes, with a major role for the HLA.

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We also replicated 18 trait-associated trans-eQTLs (including AOAH, detected at FDR 0.05) in an independent dataset comprising four different non-blood tissues (subcutaneous adipose, visceral adipose, liver and muscle, Figure S5, Table S9 and S10). Since this dataset comprised only 90 samples, it is very encouraging that 18 trans-eQTL could be replicated.