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Chunk #34 — DISCUSSION — Gene expression in alcoholics vs. controls

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Ethanol treatment of lymphoblastoid cell lines from alcoholics and non-alcoholics causes many subtle changes in gene expression.
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Thirteen genes differentially expressed in the alcoholics were associated with alcoholism in at least one of 14 GWAS (Supplementary Table 2; references therein). ZNF415 (Zinc finger 415, a transcriptional regulator) had the largest fold difference between alcoholics and controls (1.9 fold increase) and was previously identified by post mortem expression (Sokolov et al., 2003) and GWAS (Kendler et al., 2011).