Among 9401 participants whose mean age was 69.7 years and who were 53.4% women, 1822 (19.4%) had at least 1 MRI-infarct (Table 1). After meta-analysis the genomic inflation factor lambda was 0.996, indicating no significant inflation of p-values. Figure 1 shows the genome-wide plot of p-values for individual SNPs against their genomic position. None of the peaks cleared the threshold for genome-wide significance, but 51 SNPs had highly suggestive associations with p<1×10–5 (Table 2 and Appendix, Section 6 and Table A). There was no significant heterogeneity across studies for the association with these SNPs (Appendix, Section 6).
