The direction of effect for rs279845 was also opposite to that reported by Edenberg et al. (2004) and Fehr et al. (2006). While both studies reported an at-risk haplotype for AD composed of three SNPs (rs279871-rs279845-rs279836) there is some confusion given that the haplotype may differ with Edenberg and colleagues and Fehr et al. reporting T-A-T and C-T-T, respectively. However, a recent review of the role of GABAA receptors in the development of alcohol dependence indicates that the same (more frequent) haplotype was identified by Edenberg et al. and Fehr and colleagues (Enoch, 2008). While we did not successfully genotype rs279871 and rs279836, the high degree of LD spanning intron 3 to the 3’ end of GABRA2 resulted in two common complementary haplotypes, accounting for 95.6% of the estimated chromosomes, and allows a comparison of previous studies with our rs279845 data given that the alleles are ‘A’ and ‘T’.
