The at-risk rs279845 A-allele (along with the rs567926 T-allele, the at-risk rs279858 A-allele and the rs279837 T-allele) is carried on the more abundant haplotype in our population. In contrast, the at-risk (less frequent) C-C-G-T-T haplotype reported by Fehr et al. (2006) which includes rs567926 (C-allele), rs279858 (G) and rs279845 (T), and C-T-G-A-G-A-C haplotype identified by Covault et al. (2004) (including rs567926 C and rs279858 G), suggest we are observing an effect of the complementary haplotype on risk for AD in our population. Conversely, a recent case-control study of German treatment-seeking alcoholics, attempting to replicate the findings of Covault et al. (2004), identified the same (more frequent) at-risk haplotype as our study, observing T-A-T alleles at the rs567926, rs279858 and rs279837 loci (Soyka et al., 2008). Furthermore, the more frequent haplotype has been observed in Finnish alcoholics, albeit alcoholics with high tendency to be anxious (Enoch et al., 2006).
