Since GABRA2 and another GABAA receptor gene (GABRG1) are in close proximity (128 Kb apart) with moderate LD reported to extend from the 3’ end of GABRA2 to potential regulatory regions upstream of GABRG1 (Covault et al., 2008), long range LD between the four GABRA2 SNPs of interest (rs279858, rs279845, rs279826 and rs189957) and variants in surrounding genes (including GABRA4, GABRB1) was investigated in ssSNPer (Nyholt, 2006b). In each analysis, only moderate LD (r2∼0.5) was observed in the region between GABRA2 and GABRG1 loci, with lower levels (r2<0.3) detected elsewhere, suggesting that the association signal is located within GABRA2.
