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Chunk #32 — DISCUSSION

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Microstructural abnormalities in callosal fibers and their relationship with cognitive function in schizophrenia: A tract-specific analysis study.
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manner when comparing the FA values between patients with schizophrenia and healthy individuals. Several studies have examined decreased FA values in schizophrenia by segmenting the CC in the sagittal slices (Balevich et al., 2015; Knöchel et al., 2012; Li et al., 2014; Rotarska‐Jagiela et al., 2008). Balevich et al. (2015) divided the CC into five anteroposterior segments, but did not find statistically significant decrease of FA values in any specific segments. In studies with segmentation of the CC into nine regions, statistically significant FA reductions were observed in the inferior and superior genu, isthmus (Knöchel et al., 2012), anterior, middle, posterior genu, posterior body, anterior splenium (Li et al., 2014), inferior and superior genu, and splenium (Rotarska‐Jagiela et al., 2008). Whitford et al. parcellated the CC fibers into six segments based on the cortical regions they projected, and examined the difference between patients with schizophrenia and healthy participants (Whitford et al., 2010). They found a statistically significant decrease in FA of the frontal fibers in the patient group. FA values of the temporal fibers were reduced in the schizophrenia group but not statistically significantly so. The discrepancy between the current study and Whitford's study may be partially explained by differences