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Chunk #33 — DISCUSSION

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Microstructural abnormalities in callosal fibers and their relationship with cognitive function in schizophrenia: A tract-specific analysis study.
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of the frontal fibers in the patient group. FA values of the temporal fibers were reduced in the schizophrenia group but not statistically significantly so. The discrepancy between the current study and Whitford's study may be partially explained by differences in the DTI methods of analysis and in the study participants. In the current study, we divided the CC fibers based on their cortical projection regions using the two‐ROIs approach. We followed the procedures used in relevant previous studies to determine the location of ROIs and exclusion criteria (Huang et al., 2005; Lebel et al., 2010; Yamada et al., 2015), and we achieved tractography with high anatomical accuracy in each region. On the other hand, Whitford et al. segmented the CC into clusters after whole‐brain tractography. Our study participants included both men and women; however, Whitford's study included only men. TSA is useful as it delineates how fiber tracts connect functional brain regions, providing information on structural connectivity. Our results suggest microstructural abnormalities in the temporal regions of the CC white matter fibers connecting the two hemispheres.